Table 1.
Frequency of IGHV gene families expressed in leukemic cells of Iranian CLL patients
| Patients | IGHV family | Total | ||||||
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | ||
| Non‐progressive | 6 (13.6) | 0 | 30 (68.2) | 8 (18.2) | 0 | 0 | 0 | 44 |
| Progressive | 9 (22.5) | 0 | 17 (42.5) | 10 (25) | 1 (2.5) | 3 (7.5) | 0 | 40 |
| Newly diagnosed | 1 (33.3) | 0 | 2 (66.7) | 0 | 0 | 0 | 0 | 3 |
| Mutated | 6 (10.7) | 0 | 32 (57.1) | 14 (25) | 1 (1.8) | 3 (5.4) | 0 | 56 |
| Unmutated | 10 (32.3) | 0 | 17 (54.8 | 4 (12.9) | 0 | 0 | 0 | 31 |
| Total | 16 (18.4) | 0 | 49 (56.3)* | 18 (20.7) | 1 (1.1) | 3 (3.4) | 0 | 87 |
| †Normal adult B cells | 778 (28.3) | 104 (3.8) | 971 (35.3) | 770 (28) | 94 (3.4) | 33 (1.2) | 0 | 2750 |
| ‡Normal CD5+/IgM+ B cells | 27 (18.8) | 3 (5.9) | 81 (56.3) | 26 (18.1) | 2 (1.4) | 2 (1.4) | 3 (2.1) | 144 |
| ¶Known functional genes per family | 11 (21.6) | 3 (5.9) | 22 (43.1) | 11 (21.6) | 2 (3.9) | 1 (2) | 1 (2) | 51 |
Data are presented as number (%) of patients expressing the corresponding immunoglobulin variable region heavy chain (IGHV) family; All significant differences between groups are shown in bold. *Comparison between the frequency of expressed gene family in the Iranian chronic lymphocytic leukemia (CLL) population and the frequency of gene family expression in normal adult B cells (P < 0.0001). †The frequency of IGHV gene family expression in normal adult B cells represents IGHV clones identified in IgM cDNA libraries of unstimulated peripheral blood lymphocytes from healthy adults.( 41 ) ‡The frequency of expressed IGHV family genes in human peripheral CD5 + /IgM + B cells from two healthy adult donors.( 42 ) ¶The percent of functional IGHV genes per family observed as IGHV recombinants were obtained from the V BASE sequence directory.