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. 2008 Mar 28;99(4):689–695. doi: 10.1111/j.1349-7006.2008.00728.x

Figure 4.

Figure 4

The differentiation‐inducing effect of wogonin on the mophology of NB4 cells. NB4 cells were treated with either 25 µM wogonin (a) or 1 µM all‐trans retinoic acid (ATRA) (c) for 5 days. The result of control experiment (no drugs applied) is included (b) for comparison purposes. The differentiation‐inducing effects of wagonin on U937 (d, 25 µM wogonin; e, control; and f, 1 µM ATRA) and HL60 cells (g, 25 µM wogonin; h, control; and i, 1 µM ATRA) were also studied to examine cell‐type specificity of wagonin as a differentiation inducer. The cells were fixed and stained with Giemsa after treatment. Cells indicated with arrows have been induced to mature at different phases (polymorphonuclear granulocytes, myelocytes, and metamyelocytes).