Table 1.
Effects of ONO‐8711 treatment on the incidences and multiplicities of AOM‐induced intestinal tumors in rats
| Treatment | Effective no. of animals | No. of animals with tumors (%) | No. of tumors per rat (mean ± SE) | ||||
|---|---|---|---|---|---|---|---|
| Small intestine (carcinoma) | Large intestine | Small intestine (carcinoma) | Large intestine | ||||
| Adenoma | Carcinoma | Adenoma | Carcinoma | ||||
| AOM alone | 35 | 10 (29) | 15 (43) | 34 (97) | 0.29 ± 0.08 | 0.66 ± 0.15 | 3.31 ± 0.33 |
| AOM + ONO‐8711, 400 p.p.m. | 35 | 3 (9) | 16 (46) | 29 (83) | 0.09 ± 0.05* | 0.66 ± 0.15 | 2.34 ± 0.27* |
| AOM + ONO‐8711, 800 p.p.m. | 33 | 6 (18) | 16 (48) | 25 (76)* | 0.21 ± 0.08 | 0.85 ± 0.19 | 2.06 ± 0.34** |
| Saline alone | 6 | 0 | 0 | 0 | 0 | 0 | 0 |
| ONO‐8711, 800 p.p.m. | 6 | 0 | 0 | 0 | 0 | 0 | 0 |
*
Significantly different from the control value at P < 0.05.
**
Significantly different from the control value at P < 0.01.