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Effects of ONO‐8711 on cell proliferation and apoptosis in the colon
| Treatment | No. of rats tested | BrdU labeling index (mean ± SE) | Apoptotic index (mean ± SE) | |
|---|---|---|---|---|
| Normal mucosa | Carcinoma | Carcinoma | ||
| AOM alone | 4 | 3.5 ± 0.1 | 9.0 ± 1.2 | 0.39 ± 0.06 |
| AOM + ONO‐8711, 400 p.p.m. | 4 | 3.8 ± 0.1 | 5.3 ± 1.1 | 0.40 ± 0.16 |
| AOM + ONO‐8711, 800 p.p.m. | 4 | 3.3 ± 0.2 | 4.9 ± 0.8* | 0.46 ± 0.05 |
Significantly different from the control value at P < 0.05.
