A 48‐year‐old man with multiple tumors of hepatocellular carcinoma (HCC) after hepatectomy, percutaneous ethanol injection, and transcatheter arterial embolization. (a) Hypervascular HCC lesion, 1 cm in diameter, was revealed at the early phase of dynamic computed tomography (CT) before administration of sorafenib at the anterior superior segment of the liver (arrow). (b) The vascularity of this tumor disappeared 1 month after the administration of sorafenib. (c) The tumor was reduced 3 months after the administration of sorafenib. (d) Another hypervascular HCC lesion, 1 cm in diameter, was revealed at the early phase of dynamic CT before administration of sorafenib in the left lobe of the liver (arrow). (e) The vascularity of this tumor disappeared 8 months after the administration of sorafenib. (f) The tumor almost completely disappeared 10 months after the administration of sorafenib.