Table 2.

Pharmacokinetic parameters of sorafenib and metabolites M‐2, M‐4, and M‐5: sorafenib following single dose and multiple dose of 200 mg and 400 mg geometric mean (coefficient of variation)

Sorafenib	Parameter	Unit	200 mg bid				400 mg bid
			Child–Pugh A		Child–Pugh B		Child–Pugh A		Child–Pugh B
Single	n		7		6		6		8
Dose	AUC	mg*h/L	28.29	190.29 ‡	18.64	74.1	20.33	90.31	26.87	96.97
Day 1	AUC0–12	mg*h/L	5.02	190.36	2.75	61.06	3.82	86.06	3.11	88.16
	Cmax	mg/L	0.81	195.96 ‡	0.49	67.85	0.55	83.75	0.53	86.68
	Tmax	h †	7	3–12 ‡	18	4–24	8	6–24	24	4–24
	T1/2	H	25.14	30.13 ‡	30.44	35.67	22.28	12.49	27.2	45.19
Cycle 1	N		6		6		6		6
Day 14	AUC0–12	mg*h/L	25.52	75.04	15.28	55.26	33.47	60.13	29.45	59.44 §
	Cmax	mg/L	3.36	87.29	1.89	62.14	4.66	66.12	3.04	94.39
Cycle 1	N		6		6		6		5
Day 28	AUC0–12	mg*h/L	31.63	101.64	20	73.4	28.91	86.79	20.71	72.06
	Cmax	mg/L	4.22	92.32	3.32	78.65	3.32	113.47	4.01	79.12

^† Median (range),

^‡ n = 6,

^§ n = 5. AUC_0–12, area under the concentration–time curve for 0–12 h.