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. 2009 Aug 25;100(12):2426–2430. doi: 10.1111/j.1349-7006.2009.01323.x

Figure 1.

Figure 1

 Hypothetical mechanism of nitric oxide (NO) generation. NO was generated from nitrite, predominantly in hypoxic tumor tissues rather than normal tissues. DDS, drug delivery system; EPR, enhanced permeability and retention.