Table 5.

Analysis of prognostic factors for overall survival

Prognostic factors	Univariate analysis			Multivariate analysis
	HR	95% CI	P *	HR	95% CI	P **
Age (<60 versus≥60 years)	2.97	1.88–7.21	0.042	1.58	0.64–3.79	0.210
PS (0 versus 1–2)	3.98	1.13–9.91	0.019	2.65	2.44–6.63	0.058
Differentiation (Well or moderate versus poor or undifferentiated)	1.72	0.70–4.23	0.198
Stage (III versus IV)	18.61	1.10–17.28	0.000	5.96	2.40–17.30	0.000
Response (Responder versus Nonresponder † )	2.31	0.85–5.96	0.063
Bcl‐2 expression (high versus low)	2.09	0.78–5.62	0.075
MMP‐7 expression (high versus low)	11.31	7.24–29.33	0.000	5.49	1.01–8.30	0.001

Abbreviation: PS, performance status; HR, hazard ratio; 95% CI, 95% confidence interval.

^* Log‐rank test.

^** Cox proportional‐hazards regression model.

^† Stable disease, progressive disease, not evaluable.