Figure 2.

Responses of (a) SK‐N‐ASnu, (b) TNB9, and (c) TS‐N‐2nu xenografts to irinotecan (CPT‐11). Mice were administered CPT‐11 intraperitoneally for a conventional‐dose (59 mg/kg per dose) intermittent schedule, and for a low‐dose (5.9 mg/kg per dose) prolonged schedule. The arrowhead indicates the day CPT‐11 was administered. Tumor weight was calculated according to the formula: tumor weight (mg) = a × b ² × 1/2, where a is the length of the tumor and b is the width. Tumors were measured every 4 days. The results are presented as mean relative tumor weight ± SD to that on day 0 when treatment was started.