Figure 1.
Antiangiogenic and antitumor effect of low dose SN38 and ultrasound (US). The IC50 values of SN38 (A), US (B) in FU‐MMT‐3 cells. Low dose SN38 and US irradiation significantly inhibited the vascular endothelial growth factor (VEGF) mRNA expression (C) and secretion (D). In contrast, mRNA expression and secretion of TSP‐1 significantly increased in all treatment groups compared with the control (E,F) on day 4. (*P < 0.01 vs Day 4, #P < 0.01 vs Day 9).