Table 2.
Prognostic factors for overall survival by univariate and multivariate analyses
| Variable | No. patients | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| 5‐year survival rate (%) | P‐value | RR | 95% CI | P‐value | ||
| Age (years) (≥65/<65) | 51/56 | 65.8/53.4 | 0.531 | |||
| Sex (male vs female) | 85/22 | 56.1/72.7 | 0.403 | |||
| HBsAg (positive vs negative) | 29/78 | 51.0/62.3 | 0.011 | 1.14 | 0.31–4.16 | 0.844 |
| HCV (positive vs negative) | 62/45 | 66.7/46.4 | 0.004 | 2.41 | 0.75–7.69 | 0.138 |
| ICG R15 (%) (≥15 vs <15) | 50/57 | 70.3/46.8 | 0.047 | 0.69 | 0.31–1.54 | 0.362 |
| AFP (ng/mL) (≥50 vs <50) | 45/62 | 49.1/65.1 | 0.132 | |||
| PIVKA‐II (mAU/mL) (≥700 vs <700) | 30/77 | 35.0/65.6 | 0.016 | 1.91 | 0.730–5.02 | 0.188 |
| Tumor occurring (first vs recurrence) | 80/27 | 62.8/50.2 | 0.019 | 1.83 | 0.78–4.31 | 0.167 |
| No. tumors (solitary vs multiple) | 75/32 | 65.7/42.7 | 0.009 | 3.53 | 1.41–8.00 | 0.006 |
| Resection (trisegmentectomy, lobectomy, or segmentectomy/subsegmentectomy or partial resection) | 29/78 | 36.5/67.1 | 0.005 | 1.71 | 0.52–5.60 | 0.374 |
| Operation time (min) (>300 vs ≤300) | 49/58 | 43.9/72.3 | 0.053 | |||
| Intraoperative blood loss (mL) (≥1300 vs <1300) | 42/65 | 42.3/68.8 | 0.097 | |||
| Perioperative transfusion (present vs absent) | 54/53 | 49.6/66.5 | 0.599 | |||
| Tumor size (mm) (>50 vs ≤50) | 38/69 | 51.5/62.5 | 0.154 | |||
| Histological differentiation (well vs moderately and poorly) | 12/95 | 77.8/56.4 | 0.102 | |||
| pStage (I vs II/III) | 41/66 | 64.2/56.5 | 0.071 | |||
| Portal vein involvement (present vs absent) | 47/60 | 64.9/58.5 | 0.369 | |||
| Hepatic vein involvement (present vs absent) | 10/97 | 44.4/60.5 | 0.060 | |||
| Bile duct involvement (present vs absent) | 12/95 | 20.0/62.7 | 0.004 | 0.94 | 0.31–2.85 | 0.912 |
| Intrahepatic metastasis (present vs absent) | 24/83 | 29.0/66.6 | 0.001 | 3.57 | 1.13–10.50 | 0.027 |
| Non‐cancerous lesion (cirrhosis vs non‐cirrhosis) | 40/67 | 53.6/61.9 | 0.232 | |||
| GPC3 staining (positive vs negative) | 87/20 | 54.5/87.7 | 0.025 | 5.26 | 1.13–24.39 | 0.034 |
AFP, alpha‐fetoprotein; CI, confidence interval; HBsAg, hepatitis B s antigen; HCV, hepatitis C virus; ICG‐R15, indocyanine green‐retention at 15 min; PIVKA‐II, protein induced by vitamin K absence II; RR, relative risk; UICC, International Union against Cancer.