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. 2009 Oct 8;101(1):173–179. doi: 10.1111/j.1349-7006.2009.01386.x

Figure 4.

Figure 4

 The time course of plasma concentrations of unchanged KYT‐0353 in mice after intravenous administration (25.0 mg/kg). KYT‐0353 was intravenously administered to BALB/c mice at the dose of 25.0 mg/kg in a volume of 0.1 mL/10 g body weight. After administration, blood samples were withdrawn at 1.0, 5.0, 15, 30 min, and 1.0, 2.0, and 4.0 h, and centrifuged to afford plasma samples. The plasma samples, after de‐proteinization, were subjected to HPLC analysis and KYT‐0353 was quantified. The ordinate and abscissa axes indicate plasma concentrations ± SD and times after administration, respectively.