Table 5.

Mean numbers of synonymous and non‐synonymous substitutions per nucleotide site in various regions of hepatitis B virus (HBV) in the non‐hepatocellular carcinoma (HCC) and HCC groups compared with X01587

	Pre‐C/core		Pre‐S1		Pre‐S2		S		X		Pol
	Syno	Non‐syno	Syno	Non‐syno	Syno	Non‐syno	Syno	Non‐syno	Syno	Non‐syno	Syno	Non‐syno
Non‐HCC group (B)	0.0465	0.0046	0.0640	0.0145	0.0592	0.0144	0.0090	0.0070	0.0567	0.0158	0.0527	0.0138
Non‐HCC group (A)	0.0510	0.0073	0.0692	0.0157	0.0636	0.0149	0.0084	0.0076	0.0538	0.0153	0.0542	0.0137
HCC group (B)	0.0570	0.0074	0.0927	0.0183	0.0096	0.0215	0.0052	0.0081	0.0579	0.0143	0.0617	0.0134
HCC group (A)	0.0615	0.0095	0.0841	0.0191	0.0118	0.0204	0.0070	0.0089	0.0563	0.0210	0.0630	0.0139
P (non‐HCC B vs HCC B)	0.05	0.21	0.001	<0.05	<0.001	0.10	0.01	0.39	0.77	0.31	0.03	0.72
P (non‐HCC A vs HCC A)	0.07	0.40	0.08	0.12	< 0.001	0.19	0.61	0.31	0.56	<0.01	0.07	0.87

The number of synonymous and non‐synonymous substitutions per nucleotide site in the indicated regions of HBV is shown. The significance of differences (P‐value) in the indicated groups is shown. P < 0.05 is indicated by italic type. Non‐HCC group (B): at the beginning of follow‐up in patients who did not develop HCC. Non‐HCC group (A): at the end of follow‐up in patients who did not develop HCC. HCC group (B): at the beginning of follow‐up in patients who developed HCC. HCC group (A): at the diagnosis of HCC in patients who developed HCC. Non‐syno, non‐synonymous; Pol, polymerase; syno, synonymous.