Table 3.

 Comparison of normalized microRNA expression levels in glioblastoma multiforme and non‐tumor brain tissues and their association with methylation status of methylguanine‐DNA methyltransferase (MGMT) promoter

MicroRNA	Glioblastoma n = 38	Non‐tumor brain tissue† n = 10	Fold change	P‐value‡	MGMT association§ (P)
miR‐21	78.5814¶ (33.1469–237.7333)	22.7989 (19.2862–30.8386)	3.45	0.02550	0.4142
miR‐128a	0.01534 (0.005892–0.05036)	1.1798 (0.7614–7.7713)	0.01	<0.0001	0.8494
miR‐181c	0.4805 (0.1345–0.9141)	2.2363 (0.6974–3.1595)	0.21	0.0005	0.4232
miR‐195	5.4032 (0.8845–33.2029)	38.5964 (17.8927–46.8118)	0.14	0.0290	0.2928
miR‐196a	0.14790 (0.06040–0.7335)	0.01511 (0.00022–0.04707)	9.79	0.0021	0.2573
miR‐196b	0.09182 (0.01690–0.57340)	0.01978 (0.00022–0.11020)	4.64	0.0330	0.4795
miR‐221	2.3737 (1.0943–6.7427)	23.2871 (8.2249–67.7547)	0.10	0.0001	0.9749
miR‐222	7.0326 (3.2716–14.4534)	46.1839 (18.2944–99.2503)	0.15	0.0010	0.1092

†Non‐tumor brain tissue from arteriovenous malformation surgeries (×6) and commercially available adult brain RNAs (×4). ‡Mann–Whitney U‐test (bold indicates significance at P < 0.05). §Association with methylation status of MGMT promoter (Mann–Whitney U‐test). ¶Median of expression level related to RNU6B with 25th and 75th percentiles.