Effects on growth of the FU‐MMT‐1 xenografts. Each curve represents the mean and SD of the tumor (mm3) volume in each group. Either treatment with ultrasound alone or TNP‐470 alone significantly inhibited the growth of the FU‐MMT‐1 xenografts, in comparison to that of the non‐treatment group (control; Mann–Whitney‐U, P = 0.151, and P = 0.006). Moreover, a significantly enhanced effect was obtained using the combined treatment, in comparison to that of each therapy alone (Mann–Whitney‐U, vs US alone: P < 0.0001, and vs TNP‐470 alone: P < 0.0001).