Table 1.
The sonographic and immunohistochemical vascular density in FU‐MMT‐1 xenografts after 8 weeks’ treatments
| Control | US alone | TNP‐470 alone | TNP‐470 + US | |
|---|---|---|---|---|
| 1) Average sonographic vascular density (per 100 mm2) | 8.6 ± 2.1 | 7.7 ± 2.0 | 7.6 ± 2.3 | 5.5 ± 1.3 |
| 2) Highest sonographic vascular density (per 19.63 mm2) | 14.6 ± 1.8 | 12.9 ± 2.7 | 11.1 ± 1.4 | 3.6 ± 1.1 |
| 3) Average immunohistochemical microvessel density† | 49.8 ± 10.2 | 25.9 ± 12.1 | 25.1 ± 14.1 | 9.4 ± 3.2 |
| 4) Highest immunohistochemical microvessel density† | 61.3 ± 10.7 | 60.8 ± 14.7 | 50.8 ± 13.7 | 11.3 ± 2.2 |
†
Per high‐power field (0.74 mm2). 1) Control versus US: P = 0.39, or TNP‐470: P = 0.41, or TNP‐470 + US: P = 0.04. TNP‐470 versus TNP‐470 + US: P = 0.19. 2) Control versus US: P = 0.16, or TNP‐470: P = 0.002, or TNP‐470 + US: P = 0.000004. TNP‐470 + US versus US alone: P = 0.0003, or TNP‐470: P = 0.00009. 3) Control versus US: P = 0.0008, or TNP‐470: P = 0.002, or TNP‐470 + US: P = 0.0001. TNP‐470 + US versus US alone: P = 0.05, or P = 0.04. 4) Control versus US: P = 0.94, or TNP‐470: P = 0.13, or TNP‐470 + US: P = 0.000002. TNP‐470 + US versus US alone: P = 0.0001, or TNP‐470 alone: P = 0.001. Bald: P<0.05 (versus control).