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(a) Mutation analyses of human c‐Ha‐ras transgene at codon 61. A to T transversion at the second base of transgenic human c‐Ha‐ras codon 61 in papillomas detected by oligonucleotide hybridization. H, human genomic DNA; NS, skin of non‐treatment; T, tumor; TS, skin of DMBA and TPA treatment; (b) direct sequencing showed no mutation in papillomas of murine c‐Ha‐ras transgenes at codon 61.
