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Figure 4.

Figure 4

Expression of (a) cell cycle‐regulatory proteins and (b) mitotic catastrophe‐associated proteins in TE3 and TE7 cells following 24‐h treatment with 2.5 µM oxaliplatin (OHP). Cells were harvested after 24 or 48 h and subjected to western blot analysis. Survivin (c) protein (by western blot), (d) mRNA expression (by quantitative polymerase chain reaction), and (e) promoter activity (by reporter assay) in TE3 and TE7 cells after 24‐h treatment with OHP (2.5 µM for both cell lines) and cisplatin (CDDP) (2.5 µM for TE3; 3 µM for TE7). Changes in treated groups were compared with control cells. The statistical significance (P‐value) is indicated.