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. 2007 Oct 19;99(1):129–139. doi: 10.1111/j.1349-7006.2007.00637.x

Figure 5.

Figure 5

Survivin knockout using small interfering RNA (siRNA). (a) Survivin protein expression was downregulated in cells transfected with survivin‐targeted siRNA (400 nM siRNA for TE3 cells and 200 nM for TE7 cells). Treated cells were harvested at the indicated time interval and subjected to western blot analysis. (b) At 72 h after transfection, mitotic catastrophe was observed in cells transfected as in (a) with survivin‐targeted siRNA. Original magnification ×400. (c) After 72 h, the percentage of multinucleated cells was greatly increased in cells transfected with survivin‐targeted siRNA. The statistical significance (P‐value) is indicated.