Figure 4.

Plasma thymidine analog trifluorothymidine (TFT) levels in mice (a) and monkeys (b) following oral administration in the presence and absence of thymidine phosphorylase inhibitor (TPI). TFT (black circles) was administered in doses of 50 mg/kg (normal mice) or 10 mg/kg (normal monkeys), or in combination with an equimolar amount of TPI (white circles). Values are means of several experiments (n = 6 mice; n = 3 monkeys). Data were adapted from Fukushima et al. (2000; with permission).^{( 34 )}