Figure 6.

Plasma thymidine analog trifluorothymidine (TFT) levels in ICR mice (left) and monkeys (right) following oral administration in the presence and absence of thymidine phosphorylase inhibitor (TPI) at different molar ratios. TFT was administered in doses of 50 mg/kg (mice) or 10 mg/kg (monkeys). TFT plasma levels over time (a) and relationship Cmax and various TPI : TFT ratios (b) were determined. Data were adapted from Emura et al. (2005; with permission).^{( 35 )}