Figure 7.

The effect of thymidine phosphorylase inhibitor (TPI) on TP‐induced angiogenesis. Mice implanted with a chamber containing human epidermoid carcinoma cells transfected with the PD‐ECGF/TP gene (KB/TP) (A and B) and human epidermoid carcinoma cells transfected with empty control vector (KB/CV) (c, d) cells were treated with vehicle (a, c) or 50 mg/kg per day TPI (b, d). Magnification: 20 ×. Data were adapted from Matsushita et al. (1999; with permission).^{( 56 )}