Table 1.
Summary of studies in which an anti‐invasive effect of TPI on tumor cells expressing TP was demonstrated
| Study | Models | Drug Treatment (tumor cell type) | Antitumor effects | Reference |
|---|---|---|---|---|
| Matsushita et al. (1999) | Tumor implants nude mice; mouse dorsal air sac assay (human epidermoid carcinoma) | TPI alone | Decreased tumor growth rates; increased apoptosis induction; reduced microvessel density | ( 56 ) |
| Fukushima et al. (2000) | Tumor implants nude mice (human gastric carcinoma) | TFT ± TPI | Reduction of tumor volume | ( 34 ) |
| Takao et al. (2000) | Tumor implants nude mice; Matrigel invasion/chemotaxis chamber assays (human epidermoid carcinoma) | TPI alone | Reduced metastasis; inhibition of basement membrane invasion and chemotactic motility | ( 57 ) |
| Sato et al. (2003) | Tumor implants nude mice; Matrigel invasion chamber assay (human lung adenocarcinoma) | TPI alone | Reduced metastasis; inhibition of basement membrane invasion | ( 58 ) |
| Emura et al. (2004) | Tumor implants nude mice (human gastric/pancreatic carcinomas) | TAS‐102 | Decreased tumor growth rates | ( 17 ) |
| Emura et al. (2004) | Tumor implants nude mice (several different human cancers) | TAS‐102 | Decreased tumor growth rates | ( 74 ) |
| Emura et al. (2004) | Tumor implants nude mice (several different human cancers) | TAS‐102 | Decreased tumor growth rates; reduced metastasis | ( 21 ) |
| Emura et al. (2004) | Tumor implants nude rats/mice (human colorectal carcinoma) | TAS‐102 | Decreased tumor growth rates | ( 18 ) |
| Emura et al. (2005) | Tumor implants nude mice (human gastric/colorectal carcinomas) | TFT ± TPI | Decreased tumor growth rates | ( 35 ) |
| Temmink et al. (2007) | Hollow Fiber Model (normal mice) (human colorectal carcinoma) | TFT ± TPI | Decreased tumor growth rates; increased apoptosis induction | ( 61 ) |
TFT, thymidine analog trifluorothymidine; TPI, thymidine phosphorylase inhibitor.