Table 1.

List of genes with specific regards to the apoptosis pathway influenced by cyclin A1 siRNA

Genes	GenBank accession no.	Ratio (12 h)	Ratio (24 h)	Ratio (48 h)
Upregulated genes
Apoptosis: The Extrinsic Pathway
TNF receptor superfamily, member 5	AA886208	14	7.67	5
TNF (ligand) superfamily, member 10	H54629	−4.44	121.41	169.71
TNF receptor‐associated factor 1	R71691	−3.08	36.13	46.25
Downregulated genes
Apoptosis: The Intrinsic Pathway
BCL2‐antagonist of cell death	AA460291	−0.73	−1.16	−2.00
BCL2‐associated athanogene 5	AI765232	−0.74	−0.86	−1.63
Apoptosis inhibitor 5	AI972925	4.83	−14.50	−16.67
Death‐associated transcription factor 1	AA004823	1.19	−0.48	−3.86
Defender against cell death 1	AA455281	−0.27	−3.13	−4.33
E2F transcription factor 1*	AA424950	−0.25	−0.89	−2.58
Catenin (cadherin‐associated protein), alpha‐like 1	AA621315	0.20	−0.37	−0.53
HDAC1 *	AA465353	0.58	−0.96	−3.42
HDAC3 *	H79779	2.00	1.44	−0.44
Apoptosis: The Common Pathway
Baculoviral IAP repeat‐containing 5 (survivin)*	AA460685	1.00	−4.13	−12.07
Baculoviral IAP repeat‐containing 2	AA702174	−0.09	−0.78	−0.79
Oncogenes v‐myb avian myeloblastosis viral oncogene homolog‐like 2	AA457034	−2.78	−5.56	−11.06
V‐rel avian reticuloendotheliosis viral oncogene homolog A	AA443547	0.67	0.03	−2.41
Cullin 2	AA454094	−0.43	−0.73	−4.73
Forkhead box O1A (rhabdomyosarcoma)	AA448277	0.57	−1.10	−2.16
Modulators
Dual specificity phosphatase 6	AA455254	−2.57	−3.29	−5.81
Protein phosphatase 2 (formerly 2 A), catalytic subunit, alpha isoform	AA599092	2.10	−1.29	−3.57
Protein phosphatase 2 (formerly 2 A), regulatory subunit A (PR 65), alpha isoform	AA427433	−0.33	−8.17	−25.67
Protein phosphatase 2 (formerly 2 A), regulatory subunit A (PR 65), beta isoform	H57850	0.93	−4.47	−7.47
Protein phosphatase 2 (formerly 2 A), regulatory subunit A (PR 65), beta isoform	H99771	1.15	0.05	−1.52
Protein phosphatase 2 (formerly 2 A), catalytic subunit, beta isoform	AA490473	0.20	−0.80	−0.82

^* Log₂R/G ratio (R: Cy‐5, red intensity; G: Cy‐3, green intensity; P < 0.05).