Figure 1.

Primary structure and proposed actions of reversion‐inducing cysteine‐rich protein with Kazal motifs (RECK). (a) RECK contains several motifs found commonly in extracellular proteins, such as an N‐terminal signal peptide, C‐terminal glycosylphosphatidylinositol (GPI)‐anchoring signal, 6‐cysteine repeats and epidermal growth factor (EGF)‐like repeats. In addition, RECK contains three Kazal‐type serine protease inhibitor (SPI)‐like motifs. (b) Biochemical studies indicate that RECK regulates matrix metalloproteinases (MMP). Recent evidence suggests that RECK regulates some membrane‐bound proteases, such as MT1‐MMP and CD13, by recruiting them to a specific endocytic pathway (GEEC) and accelerating their degradation.