Table 2.
Correlation of clinicopathological features and type 1 insulin‐like growth factor (IGF) receptor (IGF‐1R) or IGF binding protein (IGFBP)‐3 protein expression in hepatocellular carcinoma
| Variable | IGF‐1R | IGFBP‐3 | ||||
|---|---|---|---|---|---|---|
| High (n = 58) | Low (n = 29) | P‐value | High (n = 57) | Low (n = 30) | P‐value | |
| Mean age (years) | 62.5 | 61.9 | 0.7397 | 63.2 | 60.6 | 0.1827 |
| Male : female | 45 : 13 | 22 : 7 | 0.8570 | 45 : 12 | 22 : 8 | 0.5542 |
| Mean tumor size (cm) | 3.6 | 4.6 | 0.1337 | 3.0 | 5.7 | <0.0001 |
| Liver cirrhosis | 25 (43.1%) | 12 (41.4%) | 0.8781 | 26 (45.6%) | 11 (36.7%) | 0.4223 |
| Stage | ||||||
| I/II | 31 | 12 | 0.2885 | 31 | 12 | 0.2021 |
| III/IV | 27 | 17 | 26 | 18 | ||
| Histological differentiation | ||||||
| Well/moderate/poor | 9/38/10 | 2/16/12 | 0.0557 | 11/38/8 | 0/16/14 | 0.0007 |
| Capsular invasion | 37 (63.8%) | 19 (65.5%) | 0.8742 | 31 (54.3%) | 25 (83.3%) | 0.0074 |
| Portal venous invasion | 26 (44.8%) | 14 (48.3%) | 0.7610 | 17 (29.8%) | 23 (76.7%) | <0.0001 |
| Intrahepatic metastasis | 19 (32.8%) | 10 (34.5%) | 0.8722 | 19 (33.3%) | 10 (33.3%) | >0.9999 |
| High IGF‐1R expression | – | – | 45 (77.6%) | 13 (43.3%) | 0.0008 | |