Skip to main content
. 2010 Feb 22;101(6):1493–1500. doi: 10.1111/j.1349-7006.2010.01539.x

Figure 5.

Figure 5

 Sunitinib failed to overcome F431L‐breast cancer resistance protein (BCRP)‐mediated drug resistance in K562 cells. Protein expression of BCRP in K562/F431L cells was analyzed by flow cytometry (a). The F431L‐BCRP‐expressing K562 cell lines K562/F431L‐1 and ‐3 were cultured for 5 days with SN‐38 and sunitinib (b) or fumitremorgin C (FTC) (c). Cell growth was determined with a Coulter counter and cell growth inhibition curves (% of control) are shown. Results are means ± SD of triplicate determinations.