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Reversal of P‐gp‐mediated drug resistances
| RI50 values (μmol/L) for K562/MDR | ||
|---|---|---|
| Sunitinib | CsA | |
| VCR | 0.44 ± 0.02 | 0.17 ± 0.004 |
| PTX | 0.30 ± 0.06 | 0.20 ± 0.02 |
| DOX | Not determined | 0.29 ± 0.02 |
| MXR | Not determined | 0.24 ± 0.01 |
Results are means ± SD of triplicate experiments. CsA, cyclosporin A; DOX, doxorubicin; MXR, mitoxantrone; PTX, paclitaxel; RI50, 50% reversal index; VCR, vincristine.
