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. 2010 Apr 21;101(8):1790–1796. doi: 10.1111/j.1349-7006.2010.01594.x

Figure 5.

Figure 5

 Effect of dsEcad‐215 on MDA‐MB‐453 and MCF‐7 cell migration. The cell migration of Mock‐, scramble dsRNA‐ and dsEcad‐215‐transfected cells was determined by wound closure assays. Confluent MDA‐MB‐453 and MCF‐7 cells were scratched by a micropipette tip at 72 h after transfection. Closure rates after scratching at 24 h were calculated. The closure rate of dsEcad‐215‐transfected MDA‐MB‐453 was significantly decreased (23%) compared with the closure rates of Mock‐ and scramble dsRNA‐transfected cells (P < 0.05), while there were no differences in closure rates between the later two kind of cells (P > 0.05), which were 49% and 51%, respectively. The closure rate of dsEcad‐215‐transfected MCF‐7 significantly decreased (28%) compared with the closure rates of Mock‐ and scramble dsRNA‐transfected cells (P < 0.05), whereas the closure rates of the latter two groups were 53% and 48%, respectively (P < 0.05). Columns, mean; bars, SD; *P < 0.05.