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. 2009 Jun 26;100(10):1848–1855. doi: 10.1111/j.1349-7006.2009.01262.x

Figure 4.

Figure 4

Sonic Hedgehog (SHH) pathway activation affects the cell cycle of neuroblastoma (NB) cells. Three types of NB cell lines were treated with 20 µM cyclopamine and/or 3 µg/mL SHH or the vehicle alone for 48 h and the status of cell cycling was analyzed by FACS analysis. Data represent the average ± SD of at least three independent experiments. Statistical analysis was performed using the two‐tailed Student's t‐test. V, treated with ethanol alone; C20, 20 µmol/L Cyclopamine; S3, 3 µg/mL SHH.