Figure 3.

Formation of 8‐hydroxy‐2′‐deoxyguanosine (8‐OH‐dG) and cellular proliferation and apoptosis indices in the lungs of Ogg1 ^−/– and Ogg1 ^+/+ mice treated with dimethylarsinic acid (DMA^V) at 200 p.p.m. for 72 weeks. (a) 8‐OH‐dG (c) proliferating cell nuclear antigen (PCNA) and (d) apoptosis indices. (b) 8‐OH‐dG staining pattern in DMA^V‐treated and control Ogg1 ^−/– mouse. †Normal‐appearing area; *Significant at P < 0.05 versus Ogg1 ^−/– control group; **Significant at P < 0.001 versus Ogg1 ^−/– control group; ***Significant at P < 0.0001 and ****Significant at P < 0.05 versus Ogg1 ^+/+ control group.