Figure 1.

Functional complementation for identifying a lung tumor suppressor gene at 11q23. A549 cells lost one copy of chromosome 11q. A549 cells (left) and A549 cells with the tumor suppressor gene (TSG) (right) were injected into the back of BALB/c nu/nµ mice. Tumor incidence was determined 10 weeks after injection, as described previously.^{( 3} , ^{4 )} Red bars indicate YAC with tumor suppressor activity, and blue bars indicate YAC without tumor suppressor activity.