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. 2008 Aug 14;99(8):1523–1527. doi: 10.1111/j.1349-7006.2008.00865.x

Figure 1.

Figure 1

Structure of normal monocytic leukemia zinc finger protein (MOZ) and leukemia‐associated MOZ fusion proteins. MOZ has various functional domains including H1/5 (H15; histone H1/H5–like), PHD (plant homeobox–like domain) zinc finger, B basic (b), histone acetyltranseferase (HAT) and acidic domains. S, PQ and M indicate serine‐, proline‐ and glutamine‐, and methionine‐rich domains, respectively. MOZ fusions with four known partners are shown: CBP, p300, TIF2 and the recently identified NCOA3. MOZ fusion partners contained CH1 (cystein/histidine rich domain 1), KIX (kinase‐inducible) domain, Bromodomain (Bromo), CID (CBP interacting domain) and AD (activation domain). The breakpoints in the MOZ gene and its fusion partners are shown as black arrows and blue arrows, respectively.