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Cell cycle effects at IC50 concentrations of trifluorothymidine (TFT) (T), erlotinib (E), simultaneous combination (T + E), and the sequential combinations where cells were preincubated for 24 h with TFT (T → T + E) or E (E → T + E) followed by the T + E combination in WiDR, Lovo92 and Colo320 colorectal cancer cells. Values represent means of at least four independent experiments ± SEM. *Significant differences between treated and control (C) (P < 0.05).
