Table 5.

Angiogenic receptor gene expression on mouse endothelial cells in tumors

Tumor	Treatment	mRNA copy number ratio (target gene/CD31 gene)
		Flt‐1	Flk‐1	Tie1	Tie2
	Control	0.22 ± 0.02	0.80 ± 0.07	0.56 ± 0.10	0.10 ± 0.01
MDA‐MB‐231	SQMG 5	0.22 ± 0.02	0.82 ± 0.06	0.59 ± 0.06	0.07 ± 0.01
	SQMG 20	0.26 ± 0.04	0.69 ± 0.06	0.64 ± 0.01	0.06 ± 0.02**
	Control	0.21 ± 0.01	0.82 ± 0.02	0.64 ± 0.09	0.20 ± 0.01
A549	SQMG 5	0.20 ± 0.01	0.67 ± 0.02	0.58 ± 0.10	0.08 ± 0.01**
	SQMG 20	0.24 ± 0.01	0.79 ± 0.01	1.21 ± 0.38*	0.14 ± 0.012*
	Control	0.33 ± 0.02	0.69 ± 0.02	0.58 ± 0.03	0.08 ± 0.01
WiDr	SQMG 5	0.31 ± 0.03	0.64 ± 0.01	0.59 ± 0.02	0.07 ± 0.01
	SQMG 20	0.33 ± 0.01	0.64 ± 0.02	0.63 ± 0.02	0.06 ± 0.01*
	Control	0.36 ± 0.01	1.04 ± 0.02	1.96 ± 0.58	0.20 ± 0.01
SAS	SQMG 5	0.35 ± 0.02	0.93 ± 0.05	2.16 ± 0.73	0.18 ± 0.01
	SQMG 20	0.25 ± 0.01	0.52 ± 0.03**	1.94 ± 0.43	0.11 ± 0.01**
	Control	0.16 ± 0.01	0.93 ± 0.02	1.42 ± 0.03	0.08 ± 0.01
PC‐3	SQMG 5	0.11 ± 0.13	0.73 ± 0.06	1.26 ± 0.17	0.07 ± 0.05
	SQMG 20	0.15 ± 0.02	0.78 ± 0.07	1.40 ± 0.04	0.09 ± 0.01
	Control	0.34 ± 0.03	0.74 ± 0.05	0.43 ± 0.11	0.08 ± 0.01
TE‐8	SQMG 5	ND	ND	ND	ND
	SQMG 20	0.30 ± 0.02	0.70 ± 0.04	0.44 ± 0.11	0.10 ± 0.01
	Control	0.23 ± 0.02	0.55 ± 0.06	0.43 ± 0.01	0.04 ± 0.01
LU65	SQMG 5	ND	ND	ND	ND
	SQMG 20	0.21 ± 0.21	0.69 ± 0.01	0.42 ± 0.02	0.04 ± 0.01

Data are presented as mean ± SE. ND, not done; SQMG 5, treatment of 5 mg/kg SQMG; SQMG 20, treatment of 20 mg/kg SQMG.

^* P < 0.05.

^** P < 0.01.