Figure 3.

 A molecular mechanism of myeloid dendritic cell (mDC)‐mediated natural killer (NK) activation. (a) CD11b+ bone marrow‐derived dendritic cells (BMDC) act for natural killer (NK) activation by double‐stranded (ds) RNA. NK cells express tumoricidal activity against major histocompatibility complex (MHC) low implant tumors if they are primed by polyI:C plus bone marrow‐derived dendritic cells (BMDC), but not other myeloid cells. Dendritic cell–NK cell–cell contact is essential for the induction of polyI:C‐mediated antitumor NK cells. (b) Route for mDC maturation for the induction of NK activation.^{( 39 )}