Table 1.
Human TLR and pattern molecules with MyD88‐ or Toll‐interleukin I receptor domain (TIR)‐containing adoptor molecule (TICAM‐1)‐activating properties
| Human TLR | Ligands |
|---|---|
| TLR1 | Pam3 |
| TLR2 | Pam2, Pam3, PGN |
| TLR3 | dsRNA |
| TLR4 | LPS, virus fusion units |
| TLR5 | Flagellin |
| TLR6 | Pam2 |
| TLR7 | ssRNA |
| TLR8 | ssRNA |
| TLR9 | CpG DNA |
| TLR10 | – |
| MyD88 activators (Lipoproteins, PGN) | Reference |
|---|---|
| M161Ag (MALP‐2) | ( 62 ) |
| TAN33 | ( 63 ) |
| OM‐174 | ( 64 ) |
| BCG‐CWS (Azuma lot) | ( 22 ) |
| SMP105 | ( 65 ) |
| TICAM‐1 activators (RNA, lipid A) | |
| DI RNA (stem loop) | ( 66 ) |
| Poly(A:U) | ( 67 ) |
| Poly(I:C12U) | ( 68 ) |
| PolyI:C(LC) | ( 20 ) |
| MPLA | ( 21 ) |
| Anti‐human TLR monoclonal antibodies | ||
|---|---|---|
| TLR1 | TLR1.136 | ( 58 ) |
| TLR2 | TLR2.45 | ( 59 ) |
| TLR3 | TLR3.7 | ( 60 ) |
| TLR4 | HTA125 | ( 61 ) |
| TLR6 | TLR6.127 | ( 58 ) |
dsRNA, double‐stranded RNA; TLR, Toll‐like receptor. SMP105 is a lot of BCG‐CWS that activates only TLR2.