Table 1.
List of genes downregulated by spliceostatin A (SSA) treatment in HeLa. Genes relevant to tumorigenesis (proliferation, anti‐apoptosis and angiogenesis) whose expression was down‐regulated following treatment with 200 nM SSA for 3 and 16 h in the microarray analyses are summarized. The extent of changes in the expression levels of each gene are presented on the left side as log ratios, and listed from the top according to the extent of changes on cells treated for 3 h. Genes whose expression levels were downregulated >2.8‐fold (signal log ratio ≤−1.5) are listed
| 3 h | 16 h | Gene title |
|---|---|---|
| Cell proliferation (GO : 0008283) | ||
| −3.8 | −3.8 | Cyclin‐dependent kinase 3 |
| −3.1 | −2.8 | Patched homolog 1 (Drosophila) |
| −3.1 | −2.5 | CDC‐like kinase 1 |
| −3.0 | −6.7 | Interleukin 6 receptor |
| −2.5 | −5.0 | Vascular endothelial growth factor A |
| −2.0 | −3.1 | Mature T‐cell proliferation 1 |
| −1.9 | −1.6 | MAX dimerization protein 1 |
| −1.8 | −5.1 | KIT ligand |
| −1.7 | −4.0 | TRAF interacting protein |
| −1.7 | −1.5 | Tumor necrosis factor (ligand) superfamily, member 9 |
| −1.7 | −2.4 | Taxilin alpha |
| −1.7 | −2.6 | Zinc finger E‐box binding homeobox 1 |
| −1.6 | −2.7 | CDNA clone IMAGE:5311370 |
| −1.5 | −6.3 | Interferon regulatory factor 2 |
| −1.5 | −2.6 | Transforming growth factor, alpha |
| −1.5 | −1.9 | Tripartite motif‐containing 27 |
| Anti‐apoptosis (GO : 0006916) | ||
| −3.9 | −3.1 | Neuregulin 2 |
| −3.2 | −5.2 | CASP8 and FADD‐like apoptosis regulator |
| −3.0 | −4.0 | T‐box 3 (ulnar mammary syndrome) |
| −2.7 | −7.3 | NLR family, apoptosis inhibitory protein |
| −2.3 | −1.6 | Chromobox homolog 4 (Pc class homolog, Drosophila) |
| −2.2 | −3.9 | Baculoviral IAP repeat‐containing 4 |
| −2.2 | −4.6 | NLR family, apoptosis inhibitory protein |
| −2.1 | −1.9 | BCL2/adenovirus E1B 19kDa interacting protein 1 |
| −1.9 | −2.2 | Retinoic acid receptor, alpha |
| −1.7 | −3.8 | Cytokine induced apoptosis inhibitor 1 |
| −1.6 | −3.1 | Insulin‐like growth factor 1 receptor |
| −1.6 | −4.0 | Phosphoinositide‐3‐kinase, catalytic, alpha polypeptide |
| −1.5 | −2.7 | Phosphoprotein enriched in astrocytes 15 |
| −1.5 | −4.8 | Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D |
| −1.5 | −2.4 | BCL2‐like 2 |
| −1.5 | −3.1 | Megakaryoblastic leukemia (translocation) 1 |
| Angiogenesis (GO : 0001525) | ||
| −2.5 | −5.0 | Vascular endothelial growth factor A |
| −2.1 | −3.8 | Secretogranin II (chromogranin C) |
| −2.0 | −4.1 | Angiogenic factor with G patch and FHA domains 1 |
| −1.6 | −3.5 | Jagged 1 (Alagille syndrome) |
| −1.5 | −2.6 | Transforming growth factor, alpha |