Table 1.

 Patient characteristics and gene expression

	n	MMP–7 gene exp. values Median (range)	P‐values	n	MMP–7 serum cc. Median (range)	P‐values
Age
≤65 years	46	17.25 (1.11–6155.42)	0.102	37	5.16 (0.22–36.95)	0.302
>65 years	55	14.87 (0.15–892.42)		42	5.59 (2.36–32.25)
Gender
Male	78	14.55 (0.15–2350.13)	0.262	60	5.52 (0.22–36.95)	0.900
Female	23	19.24 (0.18–6155.42)		19	5.10 (3.07–32.56)
Stage
Ta	32	11.72 (0.15–554.63)	0.793	9	4.03 (2.65–13.63)	0.486
T1	18	8.95 (0,36–891.42)	0.411	22	5.83 (2.29–12.28)	0.397
T2	9	14.23 (1.12–82.23)	0.106	12	4.65 (2.08–28.51)	0.107
T3	30	34.06 (2.02–2350.13)	0.486	24	6.59 (0.22–36.95)	0.615
T4	12	15.82 (0.18–6155.42)		12	9.76 (3.14–32.25)
Non‐invasive	50	10.25 (0.15–891.27)	0.006	31	4.80 (2.29–13.63)	0.105
Invasive	51	23.06 (0.18–6155.42)		48	5.40 (0.22–36.95)
Grade
G1	17	8.1 (0.47–42.59)	0.337	6	4.28 (2.93–12.28)	0.689
G2	37	15.26 (0.15–891.42)	0.234	25	5.10 (2.29–26.32)	0.269
G3	47	17.73 (0.18–6155.24)		48	5.71 (0.22–36.95)
Low grade (G 1–2)	54	12.41 (0.15–891.42)	0.078	31	4.80 (2.29–26.32)	0.174
High grade (G 3)	47	17.73 (0.18–6155.42)		48	5.71 (0.22–36.95)
Lymph node
N0/Nx	87	14.17 (0.15–2350.13)	0.001	65	4.88 (0.22–32.25)	0.002
N+	14	301.84 (3.96–6155.42)		14	13.92 (3.94–36.95)
Primer	48	29.43 (0.36–6155.42)	0.001	44	5.74 (2.08–36.95)	0.500
Recurrent	53	9.40 (0.15–2028.44)		35	5.22 (0.22–32.25)
Smoking
Yes	49	17.73 (0.18–2350.13)	0.232	40	5.39 (0.22–32.65)	0.519
No	37	11.90 (0.15–6155.27)		34	5.24 (2.08–36.95)
Unknown	15	–		5	–
Control	16	69.38 (0.20–987.44)	0.678	19	2.64 (1.07–6.10)	<0.001
Tumor	16	39.26 (0.52–993.43)		79	5.35 (0.22–36.95)

P‐values of statistical significance are shown in bold. –, unknown.