. 2010 Jan 20;101(5):1300–1308. doi: 10.1111/j.1349-7006.2010.01506.x

Table 2.

Cox univariate analysis

Variables	n	Overall survival			Disease‐specific survival			Metastasis‐free survival
Variables	n	HR	95% CI	P‐values	HR	95% CI	P‐values	HR	95% CI	P‐values
Age
≤65 years	77	Ref.	0.740–1.644	0.631	Ref.	0.656–1.656	0.859	Ref.	0.501–2.107	0.942
>65 years	83	1.103	0.740–1.644	0.631	1.043	0.656–1.656	0.859	1.027	0.501–2.107	0.942
Sex
Female	37	Ref.	0.600–1.530	0.857	Ref.	0.481–1.374	0.448	Ref.	0.303–1.448	0.316
Male	123	0.958	0.600–1.530	0.857	0.969	0.481–1.374	0.448	0.663	0.303–1.448	0.316
Stage
Non‐inv. (Ta‐T1)	73	Ref.	1.441–3.298	<0.001	Ref.	2.206–6.439	<0.001	Ref.	1.718–8.237	0.001
Invasive (T2‐T4)	87	2.180	1.441–3.298	<0.001	3.769	2.206–6.439	<0.001	3.761	1.718–8.237	0.001
Grade
Low grade	76	Ref.	1.603–3.619	<0.001	Ref.	2.050–5.462	<0.001	Ref.	1.751–8.863	<0.001
Hig‐‐grade	84	2.408	1.603–3.619	<0.001	3.346	2.050–5.462	<0.001	3.940	1.751–8.863	<0.001
Lymph node status
N–/Nx	137	Ref.	2.466–7.040	<0.001	Ref.	2.667–8.068	<0.001	–	–	–
N+	23	4.167	2.466–7.040	<0.001	4.638	2.667–8.068	<0.001	–	–	–
Prior recurrence
Primer	82	Ref.	0.870–1.943	0.314	Ref.	0.797–2.022	0.314	Ref.	0.478–2.012	0.958
Recurrent	78	1.301	0.870–1.943	0.314	1.270	0.797–2.022	0.314	0.981	0.478–2.012	0.958
Smoking
No	65	Ref.	0.626–1.423	0.781	Ref.	0.479–1.231	0.273	Ref.	0.291–1.259	0.178
Yes	75	0.943			0.768			0.605
Unknown	20
MMP‐7 gene exp.
Low	77	Ref.	0.993–2.952	0.053	Ref.	1.219–4.227	0.010	Ref.	1.482–11.965	0.007
High	24	1.712	0.993–2.952	0.053	2.270	1.219–4.227	0.010	4.211	1.482–11.965	0.007
in Ta‐T1 cases
Low	44	Ref.	0.246–2.969	0.805	Ref.	0.592–10.021	0.218	–	–	–
High	6	0.855	0.246–2.969	0.805	2.435	0.592–10.021	0.218	–	–	–
in T2‐T4 cases
Low	33	Ref.	0.766–2.709	0.257	Ref.	0.685–2.753	0.371	Ref.	1.445–16.717	0.011
High	18	1.440	0.766–2.709	0.257	1.374	0.685–2.753	0.371	4.914	1.445–16.717	0.011
Cystectomy	55
Low	36	Ref.	1.393–4.871	0.003	Ref.	1.480–6.177	0.002	Ref.	1.317–15.208	0.016
High	19	2.604	1.393–4.871	0.003	3.024	1.480–6.177	0.002	4.475	1.317–15.208	0.016
MMP‐7 serum cc.
Low	50	Ref.	1.201–3.627	0.009	Ref.	1.251–4.418	0.008	Ref.	1.370–8.347	0.008
High	29	2.087	1.201–3.627	0.009	2.351	1.251–4.418	0.008	3.381	1.370–8.347	0.008
in Ta–T1 cases
Low	23	Ref.	0.591–4.224	0.363	Ref.	0.544–6.885	0.308	Ref.	0.355–10.793	0.441
High	8	1.579	0.591–4.224	0.363	1.935	0.544–6.885	0.308	1.957	0.355–10.793	0.441
in T2–T4 cases
Low	27	Ref.	1.033–4.111	0.040	Ref.	0.993–4.339	0.052	Ref.	1.246–11.703	0.019
High	21	2.061	1.033–4.111	0.040	2.076	0.993–4.339	0.052	3.819	1.246–11.703	0.019
Cystectomy	58
Low	35	Ref.	1.149–3.779	0.016	Ref.	1.280–4.775	0.007	Ref.	1.321–8.449	0.011
high	23	2.084	1.149–3.779	0.016	2.472	1.280–4.775	0.007	3.341	1.321–8.449	0.011

CI, confidence interval; HR, hazard ratio; ref., referent.