Figure 4.

HER2‐specific IgG responses in 14 seroconverted patients over the vaccinations with cholesteryl pullulan (CHP)‐HER2. (a) Upper panel indicates OD₄₅₀ absorptions in sera from eight patients vaccinated CHP‐HER2 alone for the first four cycles. Lower panel indicates those from six patients given CHP‐HER2 plus granulocyte‐macrophage colony‐stimulating factor from the first vaccine cycle. (b) Enzyme‐linked immunosorbent assay for specific IgG to 146HER2 protein in serially collected sera. Diluted serum as indicated in the figure was assayed.