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. 2005 Jul 29;96(7):425–433. doi: 10.1111/j.1349-7006.2005.00063.x

Figure 8.

Figure 8

Effect of NFV on growth of LNCaP tumors in nude mice. (a) LNCaP cells were injected bilaterally subcutaneously into BALB/c nude mice, forming two tumors per mouse. NFV (60 mg/kg) was administered orally to mice five times a week for 3 weeks. Tumor volumes were measured every week. Each point represents the mean ± SD of 12 tumors. (b) Tumor weights at autopsy: After 6 weeks of treatment, tumors were removed and weighed. Results represent mean ± SD of tumor weights. Statistical significance was determined by the Mann–Whitney U‐test. Bars, SD. (c) Serum levels of PSA. After 3 weeks of treatment, blood was withdrawn from each mouse and serum levels of PSA were measured. Bars, SD. (d,e) Histology of LNCaP human prostate tumors from mice treated with NFV in vivo: After 3 weeks of growth in nude mice either with or without treatment with NFV, LNCaP tumors were removed, fixed in formalin, and stained with HE. (d) Control tumors from mice that received diluent displayed poorly differentiated adenocarcinoma (× 200). (e) Tumors from mice treated with NFV (60 mg/kg) five times a week for 3 weeks showed marked fibrosis and appearance of inflammatory cells such as giant cells (arrows; × 200).