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. 2009 Jul 8;100(10):1885–1894. doi: 10.1111/j.1349-7006.2009.01276.x

Figure 5.

Figure 5

Effects of inhibitors of MAPK and signal transducers and activators of transcription (STAT) 3 on the recombinant (r) NM23‐H1‐promoted growth and survival of acute myelogenous leukemia (AML) cells. AML cells (case 2) were cultured with or without rNM23‐H1 protein (100 ng/mL) and various inhibitors for 5 days. Viable cells were determined by MTT assay. The values are the means ± SD for four independent samples. SB202190 and SKF86002, p38 MAPK inhibitor; PD98059, MEK inhibitor; Curcumin, STAT3 inhibitor, but not specific to STAT3. Right panels have an expanded MTT scale to show the direct toxicity of these inhibitors on AML cells under conditions without rNM23‐H1.