Table 2.
Heterogeneity and pleiotropy test for fetal birth weight and childhood body mass index on frailty index.
| Exposure | Cochran Q (P) | Intercept Egger (P) | MR-PRESSO | ||
|---|---|---|---|---|---|
| IVW | MR-Egger | Raw | Outlier corrected | ||
| Own birth weight (fetal) | 280.11 (p < 0.001) | 278.28 (p < 0.001) | −0.001(0.324) | −0.068 (5.23E-04) | −0.064 (6.09E-04) |
| Offspring birth weight (maternal) | 209.35 (p < 0.001) | 205.98 (p < 0.001) | −0.002(0.258) | −0.039 (0.145) | −0.029 (0.193) |
| Childhood BMI | 21.02 (0.136) | 20.97 (0.102) | −0.001(0.855) | 0.080 (3.18E-04) | NA |
BMI, body mass index; IVW, Inverse variance weighted; P, p value; MR-PRESSO, Mendelian Randomization Pleiotropy RESidual Sum and Outlier; NA, not applicable.