Table 3.
Model building
| Model | Covariates | Objective function(Obj) | Difference in objective function | P |
|---|---|---|---|---|
| 1 | None | –5072 | ||
| 2 | BSA | –5303 | –230 | <0.0001* |
| 3 | BSA, ALB | –5538 | –235 | <0.0001* |
| 4 | BSA, ALB, HEP | –5554 | –16 | <0.0001* |
| 5 | BSA, ALB, HEP, AGP | –5574 | –20 | <0.0001* |
| 6 | BSA, ALB, AGP | –5556 | +18 | <0.0001** |
| 7 | BSA, HEP, AGP | –5469 | +105 | <0.0001** |
| 8 | BSA, ALB, HEP | –5543 | +30 | <0.0001** |
*
Compared to the previous model.
**
Compared to Model 5 (final model). AGP, α1‐acid glycoprotein; ALB, albumin; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BSA, body surface area; HEP, normal, mildly (increased ALP in combination with grade 2 elevation of AST or ALT) or moderately elevated liver function tests (increased ALP in combination with grade 3 or greater elevation of AST or ALT).