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. 2010 Jan 19;101(5):1204–1211. doi: 10.1111/j.1349-7006.2010.01499.x

Figure 5.

Figure 5

 MLN8237 induces multinucleated cells in human T‐cell leukemia virus type 1 (HTLV‐1)‐uninfected T‐cell lines and nuclear fragmentation in HTLV‐1‐infected T‐cell lines. Jurkat (a,b), CCRF‐CEM (c,d), MT‐4 (e,f), and HUT‐102 (g,h) cells were treated with 12.5 nm MLN8237 for 24 h. Nuclei were stained with DAPI (blue) (a,c,e,g). DIC: differential interference contrast images (b,d,f,h). Arrows indicate fragmentation of the nuclei. Arrowheads indicate multinucleated cells. Similar images were observed in triplicate experiments.