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. 2009 Aug 3;100(11):2077–2084. doi: 10.1111/j.1349-7006.2009.01304.x

Figure 5.

Figure 5

 Galectin‐3 (Gal‐3) depletion enhances anticancer drug sensitivity whereas overexpressing Gal‐3 increases drug resistance. Cholangiocarcinoma (CCA) cell lines KKU‐100 or KKU‐M214 were treated with either Lipofectamine (black bar) or siGal‐3‐K402 (slash bar) for 24 h, followed by treatments with various concentrations of cisplatin (A,C) or 5‐fluorouracil (5‐FU) (B,D) for a further 48 h. KKU‐M055 cells were treated with pEGFP‐C1 (control, black bar) or pEGFP‐C1‐hGal3 (Gal‐3 overexpressing cells, slash bar) for 24 h, followed by treatments with various concentrations of cisplatin (E) or 5‐FU (F) for a further 48 h as above. The number of cells was determined by sulforhodamine‐B (SRB) assay. Results are the mean ± SE (bars) of three independent experiments. * P < 0.05.