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. 2009 Oct 3;101(2):347–354. doi: 10.1111/j.1349-7006.2009.01378.x

Figure 6.

Figure 6

 Downregulation of dipeptidyl peptidase IV (DPPIV) expression and enzyme activity in epithelial ovarian carcinoma (EOC) cells with acquired paclitaxel resistance. (A) Paclitaxel sensitivity assay of parental NOS‐2 and resistant NOS‐PR cells. More pronounced chemoresistance to paclitaxel was noted in NOS‐PR compared to NOS‐2 cells. The IC50 values of NOS‐2 and NOS‐PR cells were 9.3 and 367.3 ng/mL, respectively. (B) The surface expression levels of DPPIV between the NOS‐PR and parental NOS‐2 lines. The expression level of DPPIV of NOS‐PR cells was lower than that of NOS‐2 cells. (C) Cell morphology of NOS‐2 and NOS‐PR cells. NOS‐2 cells displayed an epithelioid and cobblestone appearance (left panel). NOS‐PR cells showed the loss of cell polarity, leading to a spindle‐shaped morphology (right panel). (D) The DPPIV activity of NOS‐2 and NOS‐PR cells. DPPIV activities of both lines were almost completely inhibited by the addition of 100 μm of DPA.