Table 1.
High‐level amplifications (log2 ratio >2.0) detected in oral squamous‐cell carcinoma (OSCC) cell lines by comparative genomic hybridization (CGH)‐array analysis using MCG Cancer Array‐800 and Whole Genome Array‐4500
| Locus no. | Bacterial artificial chromosome (BAC) | Locus † | Cell line (Total 21) | Possible target gene ‡ | Number of known gene ‡ | ||
|---|---|---|---|---|---|---|---|
| Chromosomal band | Position | n | Name | ||||
| 1 | RP11‐201D16 | 3q28‐29 | chr3: 193,773,254‐193,974,704 | 1 | TOSCa‐58S1 | FGF12 | 1 |
| 2 | RP11‐81B13 | 6q15 | chr6: 88,549,158‐88,724,237 | 1 | TOSCa‐2S | None | 16 |
| RP11‐52B15 | 6q15 | chr6: 89,876,894‐89,877,257 | 1 | TOSCa‐2S | |||
| 3 | RP11‐88H8 | 6q16.3 | chr6: 102,875,956‐103,063,942 | 1 | TOSCa‐2S | None | 0 |
| 4 | RP11‐59D10 | 6q22.31 | chr6: 120,850,056‐121,030,474 | 1 | TOSCa‐55 | None | 9 |
| RP11‐311B1 | 6q22.31 | chr6: 122,660,488‐122,751,648 | 1 | TOSCa‐55 | |||
| RP11‐374A22 | 6q22.31 | chr6: 124,066,898‐124,228,515 | 1 | TOSCa‐55 | |||
| 5 | RP11‐11D14 | 7p12.3 | chr7: 47,568,937‐47,569,205 | 1 | TOSCa‐32 | None | 6 |
| 6 | RP11‐90N11 | 7p11.2 | chr7: 53,898,011‐54,057,902 | 1 | TOSCa‐2S | EGFR | 9 |
| RP11‐14K11 | 7p11.2 | chr7: 54,954,314‐54,954,933 | 3 | TOSCa‐2S, 32, 50 | |||
| RP11‐339F13 | 7p11.2 | chr7: 55,222,879‐55,348,131 | 3 | TOSCa‐2S, 32, 50 | |||
| RP11‐97P11 | 7p11.2 | chr7: 55,431,590‐55,575,284 | 3 | TOSCa‐2S, 32, 50 | |||
| RP11‐34J24 | 7p11.2 | chr7: 55,596,472‐55,596,912 | 3 | TOSCa‐2S, 32, 50 | |||
| RP11‐80L24 | 7p11.2 | chr7: 55,843,666‐55,977,803 | 3 | TOSCa‐2S, 32, 50 | |||
| 7 | RP11‐89K10 | 8q24.21 | chr8: 127,636,702‐127,799,435 | 1 | TOSCa‐45 | MYC | 2 |
| RP11‐80K22 | 8q24.21 | chr8: 128,735,610‐128884782 | 1 | TOSCa‐45 | |||
| RP11‐237F24 | 8q24.21 | chr8: 128,817,498‐128,822,855 | 1 | TOSCa‐45 | |||
| 8 | RP11‐35F11 | 11q12.3 | chr11: 62,933,912‐63,103,603 | 1 | TOSCa‐65 | CCND1, FGF3, FGF4 | 185 |
| RP11‐80B24 | 11q13.1 | chr11: 63,230,447‐63,411,884 | 1 | TOSCa‐65 | |||
| RP11‐804L21 | 11q13.3 | chr11: 69,333,918‐69,343,129 | 4 | TOSCa‐2S, 45, 55, 65 | |||
| 9 | RP11‐258C1 | 11q22.1 | chr11: 99,810,209‐99,988,933 | 1 | TOSCa‐55 | BIRC2, BIRC3, YAP1 | 29 |
| RP11‐40B14 | 11q22.1 | chr11: 99,932,373‐100,132,253 | 1 | TOSCa‐55 | |||
| RP11‐681O17 | 11q22.1 | chr11: 100,365,386‐100,536,934 | 1 | TOSCa‐55 | |||
| RP11‐750P5 | 11q22.2 | chr11: 101,623,735‐102,191,046 | 1 | TOSCa‐55 | |||
| RP11‐28I24 | 11q22.2 | chr11: 101,722,105‐101,886,737 | 1 | TOSCa‐55 | |||
| RP11‐315O6 | 11q22.2 | chr11: 101,724,723‐101,939,121 | 1 | TOSCa‐55 | |||
| RP11‐817J15 | 11q22.2 | chr11: 101,922,842‐102,095,829 | 1 | TOSCa‐55 | |||
| RP11‐750P5 | 11q22.2 | chr11: 102,010,717‐102,191,009 | 1 | TOSCa‐55 | |||
| RP11‐88H18 | 11q22.2‐22.3 | chr11: 102,253,679‐102,424,014 | 1 | TOSCa‐55 | |||
| RP11‐33F6 | 11q22.3 | chr11: 102,496,919‐102,497,333 | 1 | TOSCa‐55 | |||
| RP11‐2I22 | 11q22.3 | chr11: 102,613,696‐102,771,594 | 1 | TOSCa‐55 | |||
| RP11‐51M23 | 11q22.3 | chr11: 104,480,486‐104,480,901 | 1 | TOSCa‐55 | |||
| 10 | RP11‐319E16 | 12p13.32‐13.31 | chr12: 5,163,936‐5344,301 | 1 | SAS | KRAS2 | 230 |
| RP11‐451H11 | 12p13.31 | chr12: 5,771,103‐5927,033 | 1 | SAS | |||
| RP11‐166G2 | 12p13.31 | chr12: 5,782,525‐5783,146 | 1 | SAS | |||
| RP11‐96K24 | 12p13.1 | chr12: 13,644,252‐13,809,265 | 1 | SAS | |||
| RP11‐295I5 | 12p12.1 | chr12: 25,121,736‐25,317,791 | 1 | SAS | |||
| RP11‐64J22 | 12p12.1 | chr12: 25,882,999‐25,883,554 | 1 | SAS | |||
| RP11‐877E17 | 12p12.1 | chr12: 25,986,021‐26,163,998 | 1 | SAS | |||
| RP11‐283G6 | 12p12.1‐11.23 | chr12: 26,122,383‐26,326,610 | 1 | SAS | |||
| RP11‐53C3 | 12p12.1 | chr12: 26,255,248‐26,255,675 | 1 | SAS | |||
| RP11‐666F17 | 12p11.23 | chr12: 26,671,081‐26,857,010 | 1 | SAS | |||
| RP11‐89L4 | 12p11.23 | chr12: 26,832,206‐26,832,866 | 1 | SAS | |||
| RP11‐73I12 | 12p11.21 | chr12: 31,300,995‐31,457,338 | 1 | SAS | |||
| RP11‐517B23 | 12p11.21 | chr12: 31,362,925‐31,533,973 | 1 | SAS | |||
| 11 | RP11‐837P6 | 12q21.33‐22 | chr12: 91,147,160‐91,214,336 | 1 | TOSCa‐2S | None | 3 |
| 12 | RP11‐205M16 | 12q24.32 | chr12: 125,875,266‐126,030,621 | 1 | TOSCa‐2S | None | 0 |
| 13 | RP11‐2L22 | 14q23.1 | chr14: 58,681,521‐58,851,787 | 1 | TOSCa‐58S1 | HIF1A | 60 |
| RP11‐79M1 | 14q23.1 | chr14: 59,822,513‐59,822,977 | 1 | TOSCa‐58S1 | |||
| RP11‐193F5 | 14q23.1 | chr14: 60,271,223‐60,505,149 | 1 | TOSCa‐58S1 | |||
| RP11‐471N20 | 14q23.1 | chr14: 60,286,133‐60,457,690 | 1 | TOSCa‐58S1 | |||
| RP11‐64I19 | 14q23.1 | chr14: 60,680,813‐60,681,315 | 1 | TOSCa‐58S1 | |||
| RP11‐88L10 | 14q23.1 | chr14: 60,704,698‐60,870,460 | 1 | TOSCa‐58S1 | |||
| RP11‐436G5 | 14q23.1 | chr14: 61,022,970‐61,237,453 | 1 | TOSCa‐58S1 | |||
| RP11‐79I3 | 14q23.1 | chr14: 61,309,602‐61,449,452 | 1 | TOSCa‐58S1 | |||
| RP11‐145O12 | 14q23.2 | chr14: 62,681,383‐62,848,934 | 1 | TOSCa‐58S1 | |||
| RP11‐445J13 | 14q23.2 | chr14: 62,884,544‐63,060,428 | 1 | TOSCa‐58S1 | |||
| RP11‐14C21 | 14q23.2 | chr14: 63,712,417‐63,865,860 | 1 | TOSCa‐58S1 | |||
| RP11‐712C19 | 14q23.2 | chr14: 63,767,389‐63,819,456 | 1 | TOSCa‐58S1 | |||
| RP11‐44K16 | 14q23.2‐23.3 | chr14: 63,974,866‐64,135,774 | 1 | TOSCa‐58S1 | |||
| RP11‐63G22 | 14q23.3 | chr14: 64,463,311‐64,463,893 | 1 | TOSCa‐58S1 | |||
| RP11‐840I19 | 14q23.3 | chr14: 64,611,598‐64,638,980 | 1 | TOSCa‐58S1 | |||
| RP11‐305I24 | 14q23.3 | chr14: 66,806,287‐67,002,089 | 1 | TOSCa‐58S1 | |||
| RP11‐156E22 | 14q23.3 | chr14: 66,847,838‐67,014,199 | 1 | TOSCa‐58S1 | |||
| RP11‐79B13 | 14q24.1 | chr14: 67,744,258‐67,904,880 | 1 | TOSCa‐58S1 | |||
| RP11‐108B17 | 14q24.1 | chr14: 67,980,187‐68,130,021 | 1 | TOSCa‐58S1 | |||
†
Based on University of California Santa Cruz Genome Browser, March 2006 Assembly.
‡
Genes located around BAC, whose homozygous deletion was validated by genomic polymerase chain reaction (PCR) and/or fluorescence in situ hybridization (FISH).