Figure 2.

(a) Methylation profiles of nine CpG islands and mutation statuses of c‐kit and platelet‐derived growth factor receptor α (PDGFRA) genes. The black grid squares represent positive methylation. The open squares denote no detectable methylation. (b) Correlation between the number of methylated loci and the mutational status of gastrointestinal stromal tumors (GIST). Although GIST lacking either mutation showed relatively higher rates of multigene methylation, there were no statistical differences between GIST with c‐kit or PDGFRA mutations or those without those mutations.